Science
Mechanism of Action
This extract actively modulates skin inflammation by mitigating inflammatory chemokine production and suppressing the phosphorylation of STAT1 and ERK1/2 pathways. Its potent antioxidant capacity combats free radical damage, contributing to overall skin health and providing protection against environmental aggressors. Furthermore, it supports the strengthening of the skin's protective barrier and may help regulate sebum production, particularly beneficial for the scalp.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In an in vivo mouse model, an 80% ethanol extract at 100 mg/kg significantly improved atopic dermatitis symptoms, reducing serum immunoglobulin E levels, decreasing lymph node size and ear edema, and lessening inflammatory cell infiltration. These effects were notably stronger than those observed with hydrocortisone cream (positive control).
- 02 In vitro studies utilizing alcoholic and hot aqueous extracts at 200 mg/mL demonstrated effective inhibition of bacterial growth. Significant activity was observed against Streptococcus pyogenes, Streptococcus pneumoniae, and Klebsiella pneumoniae, with a 20 mm inhibition zone recorded for S. pyogenes.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
No specific optimal pH range for stability has been identified. Components of Cinnamomum Camphora Leaf Extract can be solubilized in both water and oil, depending on the extraction method used, such as hydrodistillation for essential oils or alcoholic/aqueous extraction.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not specifically reviewed 'Cinnamomum Camphora Formosana Leaf Extract'. However, related 'Cinnamomum Camphora (Camphor) Leaf Extract' is restricted by EWG, requiring thorough substantiation for use in verified products. While generally well-tolerated, some individuals, particularly those with sensitive skin, may experience allergic reactions or common side effects such as skin irritation, redness, or itching. Regulatory bodies, including the European Union's Cosmetics Regulation, provide specific usage guidelines to ensure safety, as higher concentrations may lead to adverse reactions. Patch testing is recommended prior to use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This extract offers valuable anti-inflammatory, antioxidant, and antimicrobial benefits for targeted skin concerns, though caution is advised for sensitive individuals due to a moderate sensitization risk and unreviewed CIR status.
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