Science
Mechanism of Action
This extract modulates skin inflammation by inhibiting the phosphorylation of ERK1/2 and STAT1 pathways, crucial for cytokine signaling. It effectively blocks the production of key inflammatory mediators like IL-1β, IL-6, and TNF-α, and reduces inflammatory chemokines. Beyond inflammation, it provides antioxidant defense by neutralizing free radicals, thereby mitigating oxidative stress and supporting anti-aging efforts. It further contributes to skin integrity by strengthening the skin barrier, refining texture, and imparting soothing effects. Additionally, it exhibits antimicrobial and antifungal properties, offering a comprehensive approach to skin well-being.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In a 2019 study, C. camphora leaves at 100 mg/kg remarkably improved atopic dermatitis symptoms in mice, evidenced by reduced serum immunoglobulin E, smaller lymph nodes, decreased ear edema, and diminished inflammatory cell infiltration.
- 02 In vitro studies on human adult low-calcium high-temperature keratinocytes revealed that the extract, at concentrations between 12.5 and 100 μg/mL, had alleviating effects on inflammatory chemokine production.
Transparency
Dusting Analysis
Insufficient data available to determine dusting patterns or thresholds for this specific extract.
The Formula
Formulation
Safety
Safety Profile
While generally well-tolerated, individual sensitivities or allergic reactions can occur. The Cinnamomum camphora plant has diverse chemotypes; cosmetic extracts are typically processed to minimize potentially undesirable components like safrole, a compound found in some essential oil fractions. The EWG Skin Deep® database rates 'Cinnamomum camphora (Camphor) Leaf Extract' as 'LOW' for concerns related to cancer, allergies & immunotoxicity, and developmental and reproductive toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cinnamomum Camphora Branch/Leaf Extract is a valuable ingredient, demonstrating significant anti-inflammatory and antioxidant benefits supported by initial research, making it suitable for sensitive and normal skin types.
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