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CINCHONA SUCCIRUBRA BARK EXTRACT.

Valuable CAS 84776-28-3 / HAIR CONDITIONING, SKIN CONDITIONING

Cinchona Succirubra Bark Extract is a multi-functional botanical ingredient recognized for its significant benefits in promoting hair growth, attributed to enhanced scalp blood flow and stimulation of hair follicles. Beyond hair care, it provides antioxidant, antimicrobial, and soothing properties for both skin and scalp health.

Summary

Hair conditioning Skin conditioning Antioxidant Astringent Antimicrobial Anti-inflammatory Soothing Purifying

Science

Mechanism of Action

This extract fosters hair growth by improving microcirculation in the scalp, elevating Vascular Endothelial Growth Factor (VEGF) levels, and activating the Wnt/β-catenin pathway, which encourages dormant hair follicles to enter the active growth (anagen) phase. Rich in phenolic compounds, it acts as an antioxidant, neutralizing free radicals that can damage skin and hair cells. Its inherent antimicrobial properties target various bacteria (e.g., *Bacillus subtilis*, *E. coli*) and fungi, contributing to a healthier scalp environment and addressing concerns such as dandruff. Topically, it refines skin and scalp as an astringent and purifier, while providing anti-inflammatory and conditioning benefits, supporting both skin health and natural hair color integrity.

Research

Clinical Evidence

Medium confidence
Effective range 0.007172–20%
Optimal

20%

Key findings

  1. 01 A cream formulation containing 20% Cinchona succirubra extract demonstrated effective hair fertilizer activity, good physical stability, and was found to be non-irritant in acute dermal irritation tests on rabbits.
  2. 02 An aqueous extract of a related species, *Cinchona officinalis*, exhibited antioxidant activity with an IC50 of 71.72 μg/ml (0.007172%).

Transparency

Dusting Analysis

Not commonly dusted

The provided research data does not contain information regarding ingredient dusting in formulations or specific percentages that would indicate insufficient active concentration for efficacy.

The Formula

Formulation

Solubility
Unknown
Optimal pH 6.41 – 6.55
0 7 14

Stability

Cinchona extract is practically insoluble in water, suggesting that specialized delivery systems, such as creams, are necessary for optimal penetration into hair follicles. Tinctures are commonly prepared utilizing alcohol or glycerin for efficient extraction. An optimal cream formulation containing 20% Cinchona extract was found to be stable at a pH of 6.48±0.07, indicating an optimal pH range between 6.41 and 6.55.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
20%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel and the Scientific Committee on Consumer Safety (SCCS) have not specifically evaluated Cinchona Succirubra Bark Extract. However, *Cinchona spp.* extract is recognized as generally safe (GRAS) by the U.S. FDA as a flavoring agent in foods. An acute dermal irritation test on rabbits showed a 20% extract cream to be non-irritant. EWG assigns a 'LOW' concern rating for cancer, allergies & immunotoxicity, developmental and reproductive toxicity, and use restrictions, while SkinSAFE classifies it as 'Irritant Free'. Nonetheless, caution is advised for individuals with pre-existing scalp conditions like eczema or psoriasis, as active compounds may potentially exacerbate irritation. Excessive systemic exposure, though highly improbable from topical use, could theoretically lead to Cinchonism (quinine toxicity).

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Cinchona Succirubra Bark Extract is a valuable botanical ingredient, particularly for scalp and hair treatments, offering robust hair growth promotion, antioxidant protection, and broad skin compatibility with a low risk of irritation.

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