Science
Mechanism of Action
This extract functions by optimizing nutrient and oxygen delivery to hair follicles through improved microcirculation, crucial for supporting robust hair growth from root to tip. It actively stimulates hair follicles and dermal papilla by activating the Wnt/b-catenin pathway and increasing Vascular Endothelial Growth Factor (VEGF) production, thereby strengthening roots and contributing to hair fall reduction. Its rich content of Cinchona alkaloids and phenolic compounds imbues it with antioxidant, antimicrobial, and anti-inflammatory capabilities, further complemented by its astringent properties.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Aqueous extracts from related Cinchona species are noted for being free of essential oils and fragrance allergens. Certain alkaloids within Cinchona bark are known to be soluble in hydro-alcoholic solutions, with ethanol also serving as a common solvent for extraction.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) and Scientific Committee on Consumer Safety (SCCS) have not formally reviewed Cinchona Calisaya Bark Extract for cosmetic applications. While a related Cinchona bark extract is approved by the FDA as a natural food flavoring, with a maximum total cinchona alkaloid level of 83 ppm in beverages, this does not directly translate to cosmetic safety limits. All cosmetic ingredients in Europe are subject to strict regulatory safety assessments.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cinchona Calisaya Bark Extract is a valuable ingredient, particularly for promoting hair and scalp health through enhanced circulation, follicle stimulation, and its inherent antioxidant and anti-inflammatory properties, despite awaiting formal cosmetic safety reviews by CIR or SCCS.
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