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CI 75125.

Valuable CAS 502-65-8 / COLORANT

CI 75125, commonly known as Annatto, is a natural carotenoid-derived colorant used to impart yellow to orange shades in cosmetic formulations. Beyond its primary role as a pigment, its chemical association with Lycopene and psi,psi-Carotene suggests potential secondary benefits as an antioxidant.

cosmetic colorant antioxidant

Science

CI 75125 functions primarily as a cosmetic colorant, effectively delivering yellow to orange pigmentation across a range of beauty products. Chemically, it is classified as a carotenoid, associating with compounds such as Lycopene and psi,psi-Carotene. Carotenoids are broadly recognized for their antioxidant capabilities, with related molecules like beta-carotene demonstrating efficacy in neutralizing free radicals and mitigating oxidative stress to support skin health.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

For enhanced stability against heat and light degradation, especially for colors derived from annatto, the use of encapsulated grades is advisable. Ingredients containing CI 75125 should be protected from direct light and oxygen and stored in a cool, dry environment. Formulators should select the appropriate form—oil-soluble bixin for fat-based systems or water-soluble norbixin for aqueous formulations—to ensure optimal performance.


Safety

CIR Status
Safe as used
Sensitization risk Low

CI 75125 is a regulated natural dye approved for cosmetic applications within the European Union (listed in Annex IV of EC No. 1223/2009) and subject to FDA approval in the United States. Its safety is well-regarded, with the Cosmetic Ingredient Review (CIR) often aligning with FDA assessments for related carotenoids. The Environmental Working Group (EWG) assigns a low hazard rating, indicating minimal concerns for cancer, allergies, immunotoxicity, and developmental or reproductive toxicity.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

CI 75125 is a well-established, safe, and versatile natural colorant providing desirable yellow-to-orange hues, complemented by potential antioxidant properties for comprehensive skin benefits.


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