Science
Mechanism of Action
This extract exerts its multifaceted effects through robust antioxidant and anti-inflammatory pathways. Its high concentration of flavonoids, including quercetin and luteolin, scavenges free radicals, thereby mitigating oxidative stress and reducing visible signs of premature aging. Anti-inflammatory actions are observed through the suppression of reactive oxygen species and nitric oxide production, and the downregulation of iNOS and IL-1β expression, primarily by inhibiting the NF-κB signaling pathway. This contributes to a reduction in redness and irritation, simultaneously fortifying the skin’s hydrolipidic barrier for enhanced moisture retention and defense. For hair, it stimulates the proliferation and differentiation of pluripotent epidermal matrix cells, epithelial stem cells, and crucially, follicular dermal papilla cells, supporting hair shaft production and encouraging telogen follicles to enter the active anagen growth phase.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated increased proliferation of follicular dermal papilla cells, supporting hair growth in vitro, at concentrations between 0.00001% and 0.001%.
- 02 Significantly reduced LPS-induced upregulation of iNOS and COX-2, indicating anti-inflammatory effects, at a concentration of 0.01% (ethanol extract from flowers).
- 03 Exhibited strong antioxidant activity, as evidenced by IC₅₀ values of 186.04 μg/ml (DPPH assay) and 94.56 μg/ml (ABTS assay).
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While no specific optimal pH range for stability in cosmetic formulations was definitively established, studies involving similar chrysanthemum extracts utilized NaAc buffer at pH 5.5, and a zebrafish study incorporated the extract in filtered water with a pH range of 6.8 to 7.5. Further formulation-specific stability testing is advised.
Safety
Safety Profile
Generally considered a safe cosmetic ingredient. Dermatological studies suggest it rarely causes allergic reactions or skin irritation, making it suitable for sensitive skin. A patch test is recommended before widespread use, particularly for individuals with known adverse reactions to other chrysanthemum species.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This versatile botanical extract offers significant antioxidant and anti-inflammatory benefits for comprehensive skin health, complemented by promising in vitro hair growth promotion and a generally low sensitization risk across all skin types.
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References
Sources