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Moumoujus

CHRYSANTHEMUM PARTHENIUM EXTRACT.

Valuable CAS 89997-65-9 / SKIN CONDITIONING

Derived from the feverfew plant, Chrysanthemum Parthenium Extract is a powerful botanical renowned for its potent antioxidant and anti-inflammatory benefits. It actively shields skin from environmental stressors and free radical damage, while simultaneously calming visible irritation and redness. For optimal skin compatibility, a meticulously processed parthenolide-free extract is essential.

Summary

antioxidant anti-inflammatory skin soothing anti-aging skin conditioning antimicrobial astringent

Science

Mechanism of Action

This extract operates through multiple pathways, primarily leveraging its robust antioxidant capabilities to neutralize free radicals and mitigate oxidative stress, thereby helping to preserve skin elasticity and firmness and diminish signs of aging. It exerts significant anti-inflammatory effects, effectively soothing irritated skin and reducing visible redness. Its active constituents, including flavonoids, contribute to these protective actions, while certain volatile oils may offer refreshing and mild astringent properties. The extract also possesses antimicrobial activity. Crucially, the sensitizing compound parthenolide must be removed to ensure its beneficial topical application.

Research

Clinical Evidence

Medium confidence
Effective range ≤2.5%
Optimal

1%

Key findings

  1. 01 A clinical study demonstrated that a 1.0% concentration of Chrysanthemum Parthenium Extract offered optimal antioxidant activity, significantly reducing reactive oxygen species (ROS) in human keratinocytes and fibroblasts under induced oxidative stress. While concentrations below 2.5% showed strong antioxidant benefits, amounts exceeding 5.0% paradoxically led to an increase in oxidative stress within these same cell types.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.5%
Red flag below
5%

The extract exhibits optimal antioxidant efficacy at 1.0%, with notable benefits observed up to 2.5%. Incorporating it at concentrations significantly below 0.5% may suggest 'dusting,' where the ingredient is present without providing meaningful benefit. Conversely, concentrations surpassing 5.0% are actively detrimental, inducing oxidative stress in skin cells.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The primary safety consideration for Chrysanthemum Parthenium Extract is its potential to cause sensitization and allergic contact dermatitis, attributed to the sesquiterpene lactone parthenolide. To ensure the extract is non-problematic and delivers its soothing benefits, it must be formulated as parthenolide-free. The CIR has not formally reviewed this ingredient. Additionally, concentrations above 5.0% are contraindicated for topical use due to their capacity to induce oxidative stress.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Chrysanthemum Parthenium Extract is a valuable ingredient, delivering significant antioxidant and soothing benefits when precisely formulated to be parthenolide-free and utilized within effective, non-oxidative concentration ranges.

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