Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

CHRYSANTHELLUM INDICUM EXTRACT.

Valuable CAS 223748-24-1 / SKIN CONDITIONING

Chrysanthellum Indicum Extract is a botanical powerhouse revered for its multifaceted benefits, primarily its potent anti-inflammatory and antioxidant capabilities. It actively reduces redness and irritation while promoting a brighter, more even skin tone and supporting overall skin health.

Summary

Skin Conditioning Anti-inflammatory Antioxidant Skin Brightening Reduces Hyperpigmentation Moisturizing Antibacterial Collagen Boosting Strengthens Skin Barrier Balances Microbiome

Science

Mechanism of Action

This extract operates through several key pathways to enhance skin health. It exerts potent anti-inflammatory effects by inhibiting inflammatory mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), TNF-α, and IL-1β via the suppression of MAPKs and NF-κB-dependent pathways, effectively reducing redness, irritation, and swelling. As an antioxidant, it neutralizes reactive oxygen species, protecting the skin from free radical damage and photoaging. For skin brightening, it inhibits tyrosinase activity, an enzyme crucial for melanin synthesis, thereby diminishing dark spots and hyperpigmentation. Furthermore, it aids in maintaining hydration, enhancing skin texture and elasticity, and possesses antibacterial properties to combat acne and prevent clogged pores. It also supports collagen production, strengthens the skin barrier, and helps balance the skin's microbiome.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–30%
Optimal

N/A

Key findings

  1. 01 Application of cosmetic formulations containing 0.5% Chrysanthemum indicum water extract time-dependently decreased melanin levels over 6 weeks. It also dose-dependently inhibited mushroom tyrosinase activity in vitro, suggesting its potential as a natural skin-lightening agent.
  2. 02 Topical application of Chrysanthemum indicum L. extracts (5% and 30%) in mice with atopic dermatitis-like symptoms significantly mitigated clinical severity, ear thickness, and mast cell/eosinophil counts over 5 weeks. The 30% concentration demonstrated efficacy comparable to 0.1% hydrocortisone, without observed adverse effects.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.5%
Red flag below
<0.5% (for brightening benefits); <5% (for anti-inflammatory benefits)%

This ingredient has demonstrated efficacy at specific concentrations: 0.5% for skin brightening and 5-30% for significant anti-inflammatory effects. Formulations containing concentrations below these thresholds may not deliver the claimed benefits effectively.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Typically formulated in water or water/propylene glycol systems, indicating good stability in aqueous bases.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) has not specifically evaluated Chrysanthellum Indicum Extract, it is generally considered well-tolerated. However, a mild irritation or allergic reaction is possible in susceptible individuals, particularly those with sensitive skin. A preliminary patch test is recommended. A separate safety evaluation of Chrysanthemum indicum L. flower oil indicated no acute oral toxicity or mutagenicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Chrysanthellum Indicum Extract is a valuable botanical ingredient offering clinically supported anti-inflammatory, antioxidant, and brightening benefits suitable for a wide range of skin types.

Related

Similar Ingredients

Finding similar ingredients…