Science
Mechanism of Action
This extract functions as a powerful antioxidant, protecting human dermal fibroblasts and epidermal keratinocytes from oxidative damage, primarily due to its content of phenolic acids and lipophilic flavonoid aglycones. It promotes robust skin repair by enhancing the proliferation of fibroblasts, endothelial cells, and keratinocytes, stimulating keratinocyte migration, and up-regulating the production of extracellular matrix proteins and basement membrane components. Furthermore, it exhibits anti-inflammatory, antimicrobial, and haemostatic effects, while strengthening the dermal matrix through increased collagen and decorin production and stimulating fibroblast activity for comprehensive wound repair.
Research
Clinical Evidence
High confidence0.001-0.1%
Transparency
Dusting Analysis
While Chromolaena Odorata Leaf Extract demonstrates a broad effective range for topical use up to 10%, the 'most preferably' effective concentration for key anti-aging and skin improvement benefits is cited as 0.001-0.1%. Concentrations significantly below this optimal range, particularly under 0.001%, may indicate 'dusting' where the ingredient is included for marketing claims rather than delivering its full clinical efficacy.
The Formula
Formulation
Stability
The extract exhibits stability and efficacy within the typical physiological pH range of the skin, with an ethanol extract noted at pH 5.5 and a gel formulation maintaining a skin-friendly pH of 5.93 ± 0.17. Its active compounds can be extracted using both polar (e.g., water, ethanol, methanol) and less polar (e.g., hexane) solvents, indicating the presence of both water-soluble and oil-soluble components, allowing for versatile formulation across various product types.
Safety
Safety Profile
No specific CIR, SCCS, or FDA safety assessment status is available. In vitro studies on keratinocyte, fibroblast, and macrophage cells, along with brine shrimp lethality tests and acute animal toxicity studies in white rats, generally suggest low toxicity. However, a noted likelihood of irritation, inflammation, or dryness has been reported by third parties, especially when combined with other potentially problematic ingredients, indicating a moderate sensitization risk for certain individuals.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Chromolaena Odorata Leaf Extract is a valuable botanical ingredient, offering comprehensive benefits for skin health including potent antioxidant protection, accelerated wound healing, and robust anti-aging effects through enhanced collagen and decorin production, making it a strong candidate for precision skincare despite a moderate irritation risk for sensitive individuals.
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