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Moumoujus

CHOLECALCIFEROL/YEAST POLYPEPTIDE.

Valuable CAS - / SKIN CONDITIONING

This advanced complex renders the typically oil-soluble Vitamin D3 (Cholecalciferol) water-dispersible through conjugation with low molecular weight yeast polypeptides. This innovative formulation significantly enhances dermal absorption and bioavailability while minimizing potential irritation or toxicity.

Summary

Emollient Skin-Conditioning Agent Firming Nourishing Anti-inflammatory Wound Healing Antimicrobial Barrier Support Anti-aging Elasticity Enhancement

Science

Mechanism of Action

Once absorbed, the Vitamin D3 within the complex becomes integral to various dermatological processes. It is vital for cellular growth and maintenance, particularly enhancing skin elasticity and fortifying the epidermal barrier by promoting keratinocyte differentiation. This ingredient actively modulates cell proliferation, supports efficient wound healing through repair and regeneration, and exhibits potent anti-inflammatory effects beneficial for conditions such as eczema, psoriasis, and acne. It further bolsters the skin's innate immune system, guarding against pathogens, and by stimulating cell regeneration, it contributes to improving skin texture, resilience, and visibly diminishes fine lines and wrinkles.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

The Vitamin D3 component maintains optimal stability within a pH range of 5 to 8, experiencing a significant decline below pH 5. To mitigate negative impacts from metal ions and acidic conditions in aqueous solutions, co-formulation with chelating agents such as EDTA and antioxidants like ascorbic acid or citric acid is recommended.

Synergies

  • chelating agents (e.g., EDTA)
  • antioxidants (e.g., ascorbic acid, citric acid)

Conflicts

  • strong acids
  • certain metal ions

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Cholecalciferol (Vitamin D3) is an approved food additive and Saccharomyces cerevisiae is Generally Recognized As Safe (GRAS) for food, these statuses do not directly apply to topical cosmetic use of the complex. The CIR Expert Panel is currently reviewing 'Yeast-derived ingredients,' including yeast polypeptides, with a Draft Final Report expected in June 2024. However, the complexation of Cholecalciferol with yeast polypeptides is specifically noted to significantly reduce potential toxicity or irritation, rendering it generally non-irritating.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This complex offers a highly bioavailable form of Vitamin D3, delivering extensive benefits for skin barrier integrity, immune function, elasticity, and anti-aging, with a favorable safety profile.

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