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CHOLECALCIFEROL PEG-12 ETHER.

Avoid / SKIN CONDITIONING

CHOLECALCIFEROL PEG-12 ETHER is a polyethylene glycol derivative of Cholecalciferol (Vitamin D3), designed as a skin conditioning agent. The PEG-12 component is incorporated to potentially enhance its solubility and improve skin delivery.

Summary

Skin Conditioning

Science

Mechanism of Action

This ingredient functions by delivering Cholecalciferol, whose biologically active form, calcitriol, interacts with vitamin D receptors (VDRs) in the skin. These VDR-mediated pathways are integral to regulating critical cellular processes such as the growth and differentiation of epidermal keratinocytes, contributing to overall skin health.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 5 – 8
0 7 14

Stability

Cholecalciferol is inherently unstable, degrading upon exposure to direct light, moisture, and heat. In aqueous environments, metal ions and acidic conditions are primary destabilizing factors. Its stability can be enhanced by incorporating antioxidants like ascorbic acid and citric acid, as well as chelating agents such as EDTA. Polyethylene glycols are also known to improve the stability of fat-soluble vitamins, with Cholecalciferol-PEG conjugate micelles showing stability for 2 months when stored at 2–8°C.

Synergies

  • ascorbic acid
  • citric acid
  • EDTA
  • polyethylene glycols

Conflicts

  • strong oxidizers
  • alkalis
  • acids
  • carboxylic acid anhydrides
  • acid halides
  • metal ions

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Unknown

Cholecalciferol is explicitly banned for use in cosmetics under the European Cosmetics Directive. While specific safety data for CHOLECALCIFEROL PEG-12 ETHER in cosmetics is absent, its parent compound, Cholecalciferol, is chemically volatile, reacting violently with strong oxidizers, alkalis, acids, and acid derivatives. Additionally, Cholecalciferol has been flagged with a 'High alert' for reproduction/development effects in the context of its use as a rodenticide, indicating potential severe adverse effects in humans.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its regulatory ban in European cosmetics and the significant reproductive/developmental toxicity concerns associated with its active component, CHOLECALCIFEROL PEG-12 ETHER is not recommended for use in skincare formulations.

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