Science
Mechanism of Action
This extract operates through a four-pronged approach: it inhibits Advanced Glycation End products (AGEs) to maintain protein flexibility, stimulates Type I collagen synthesis while suppressing collagen-degrading enzymes (MMP-1/9), activates the Nrf2/HO-1 pathway to neutralize UV-induced ROS, and significantly upregulates barrier genes like TGM1 and Keratins for enhanced structural integrity.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 Demonstrated a 4.4x increase in KRT10 barrier protein expression and a 43% boost in collagen-related gene COL1A2 at a 0.5% concentration.
- 02 Shown to reduce cellular melanin content by 30% and decrease MMP-9 enzyme activity by 33% in human fibroblast models.
- 03 Proven to scavenge reactive oxygen species with an IC50 of 84.7 μg/mL, providing significant protection against UV-induced glycation stress.
Transparency
Dusting Analysis
While many formulas include Djulis for its exotic appeal at trace levels, clinical data indicates that structural benefits, such as collagen gene upregulation and barrier repair, require a threshold of at least 0.5% to be biologically significant.
The Formula
Formulation
Stability
Contains pH-sensitive betacyanin pigments; stability is optimized at approximately pH 5.3. The extract is thermolabile and should not be heated above 50°C during the formulation process.
Synergies
- Niacinamide
- Hyaluronic Acid
- Vitamin C
Conflicts
- High thermal processing
- Strong oxidizing agents
- Highly alkaline environments
Safety
Safety Profile
Recognized as a safe staple food source (Djulis) with no reported dermal irritancy; filed as a New Cosmetic Raw Material with the Taiwan FDA in 2022.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated botanical powerhouse that effectively bridges the gap between traditional antioxidant protection and advanced genetic barrier support.
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References
Sources