Science
Mechanism of Action
It functions through a multi-pathway approach: active terpenoids like bisabolol and chamazulene inhibit inflammatory mediators such as leukotriene B4 and prostaglandin E2. Simultaneously, the flavonoid apigenin boosts the expression of filaggrin and loricrin proteins to strengthen the skin barrier while stimulating natural hyaluronic acid synthesis for deep-layer hydration.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 A Human Repeated Insult Patch Test (HRIPT) at 0.2% demonstrated zero irritation or sensitization across 105 subjects.
- 02 Epicutaneous testing at 0.3% confirmed non-irritating status for both sensitive and normal skin types.
- 03 In vitro analysis at 5.0%-10.0% concentrations showed significant reduction in UV-induced erythema and inhibition of inflammatory markers.
Transparency
Dusting Analysis
While often included at trace amounts for marketing appeal, concentrations below 0.3% are unlikely to provide the measurable anti-inflammatory benefits observed in clinical safety and efficacy trials.
The Formula
Formulation
Stability
Active flavonoids are highly sensitive to alkaline environments; degradation occurs rapidly at a pH above 7.0. The extract is also thermolabile and should not be exposed to temperatures exceeding 40°C.
Synergies
- Bisabolol
- Hyaluronic Acid
- Glycerin
- Panthenol
Conflicts
- High pH agents
- Alkaline buffers
Safety
Safety Profile
Generally regarded as safe; however, individuals with a known allergy to the Asteraceae/Compositae family (e.g., ragweed, daisies) should conduct a patch test prior to use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An excellent, low-irritancy botanical water that provides authentic physiological benefits for barrier repair and inflammation control when formulated at active levels.
Related
Similar Ingredients
Finding similar ingredients…