Science
Mechanism of Action
This lipophilic molecule penetrates the skin barrier to deliver a vital precursor that converts into NAD+. By replenishing NAD+ levels, it fuels ATP production for cellular energy, activates sirtuin 'longevity' proteins, and powers PARP enzymes responsible for repairing DNA damage.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Clinical research conducted by Boots No7 and the University of Manchester (2024) demonstrated that a 1% concentration significantly boosts cellular NAD+ levels, leading to visible improvements in skin resilience, elasticity, and damage reversal within 28 days.
Transparency
Dusting Analysis
As a relatively new and high-cost bio-active, it is susceptible to 'label claim' dusting. Formulations containing less than 0.5% may not provide the energetic surge required for DNA repair and sirtuin activation.
The Formula
Formulation
Stability
Highly sensitive to acidic environments below pH 4.0, which can trigger hydrolysis. The cetyl-chain modification makes it ideal for stabilizing within the oil phase of emulsions.
Synergies
- Peptides
- Antioxidants
- Barrier lipids
Conflicts
- Strong acids
- Strong oxidizers
Safety
Safety Profile
Listed as a safe antioxidant and skin-conditioning agent in the EU CosIng database. It is generally well-tolerated without the 'flushing' effect sometimes associated with traditional Niacin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated NAD+ booster that offers superior penetration and stability for revitalizing aged or environmentally compromised skin.
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