Science
Mechanism of Action
By integrating a cetyl chain into the riboside structure, this ingredient achieves superior penetration through the stratum corneum compared to standard Vitamin B3. Once absorbed, it converts into Nicotinamide Adenine Dinucleotide (NAD+), which stimulates ATP production for cellular repair, activates SIRT1 longevity proteins, and protects DNA from oxidative stress.
Research
Clinical Evidence
High confidence0.1%
Key findings
- 01 Clinical evaluation of 32 subjects demonstrated a skin appearance up to 8 years younger after 42 days of application.
- 02 In vivo testing at 0.1% showed significant improvements in skin sagging, fine lines, and structural tone within 8 weeks.
- 03 In vitro data confirms a significant boost in cellular NAD+ levels and activation of sirtuin pathways for enhanced barrier longevity.
Transparency
Dusting Analysis
Because this ingredient is effective at ultra-low concentrations (0.1%), it is rarely 'dusted' in the traditional sense, though products using less than 0.1% may not deliver the full age-reversing benefits observed in clinical trials.
The Formula
Formulation
Stability
Most stable within the 5.0–6.0 pH range. Exposure to extreme pH levels can trigger hydrolysis of the riboside bond. While amphiphilic, it is typically incorporated into the oil phase of emulsions.
Synergies
- Niacinamide
- Peptides
- Ceramides
Conflicts
- Strong acids
- Strong bases
- Oxidizing agents
Safety
Safety Profile
Classified as non-irritating and suitable for sensitive skin. It is currently recognized in the EU Cosmetic Ingredient Glossary.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated, bioavailable alternative to traditional B3 that offers a measurable 'youth-span' extension for skin cells through NAD+ optimization.
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