Science
Mechanism of Action
Cetoleth-22 functions by significantly lowering interfacial tension, facilitating the uniform dispersion of oils within aqueous systems. Beyond its emulsifying properties, its high HLB (Hydrophilic-Lipophilic Balance) value makes it an effective solubilizer for lipophilic actives, optimizing their bioavailability and penetration into the stratum corneum.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 Clinical patch testing (HRIPT) confirms that at 1.5% concentration, the ingredient is non-sensitizing and produces minimal irritation.
- 02 Comparative research on oxyethylene chain lengths indicates that mid-range ethoxylation levels, such as those found in Cetoleth-22, provide an optimal balance for enhancing the skin penetration of flavonoids like quercetin.
Transparency
Dusting Analysis
As a functional ingredient rather than a primary active, it is rarely 'dusted' for marketing purposes; however, concentrations below 1% may indicate it is being used solely as a solubilizer for fragrance rather than a primary emulsification system.
The Formula
Formulation
Stability
Demonstrates exceptional stability across a broad pH spectrum and maintains integrity in high-electrolyte environments (hard water). It is compatible across anionic, cationic, and non-ionic surfactant systems.
Synergies
- Flavonoids
- Lipophilic active ingredients
- Co-emulsifiers
Conflicts
- Strong oxidizing agents
- Phenolic preservatives
Safety
Safety Profile
Safe for general topical use; however, it should be avoided on severely damaged or burned skin to prevent potential systemic absorption of PEG components.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A reliable and versatile stabilizer that not only ensures formula integrity but also actively supports the delivery of key lipid-soluble nutrients.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources