Science
Mechanism of Action
This extract functions as a dual-action enzymatic inhibitor, targeting tyrosinase to modulate melanin production and collagenase to prevent the breakdown of dermal fibers. Its high concentration of gallic acid, quercetin, and myricetin-3-O-rhamnoside scavenges reactive oxygen species (ROS) while stimulating fibroblast activity to support barrier repair and reduce inflammatory markers.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 A 28-day clinical trial utilizing a 3% concentration demonstrated significant improvements in skin tone uniformity and a measurable reduction in UV-induced hyperpigmentation.
- 02 In vitro analysis on B16F10 cells showed a 45% reduction in melanin content at concentrations as low as 12.5 μg/ml without compromising cell viability.
- 03 Research confirmed protection against oxidative DNA damage in human skin fibroblasts and potent ROS-scavenging capabilities in neutrophils.
Transparency
Dusting Analysis
While often included at trace levels for 'label claims' due to its botanical origin, clinical data suggests that a minimum concentration of 1% is required for antioxidant benefits, with 3% being the benchmark for visible depigmentation.
The Formula
Formulation
Stability
Highly stable in aqueous systems; bioactive polyphenols remain resilient across a broad pH range (3.5–11.0), though the formula should remain slightly acidic to neutral for peak cosmetic performance.
Synergies
- Vitamin C
- Niacinamide
- Hyaluronic Acid
Conflicts
- Strong oxidizing agents
- Temperatures exceeding 80°C
Safety
Safety Profile
Recognized as GRAS (Generally Recognized as Safe) by the FDA; while grouped with seed and fruit extracts in CIR assessments, it shows excellent biocompatibility.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance botanical active that offers clinically backed depigmentation and robust antioxidant protection for all skin types.
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References
Sources