Science
Mechanism of Action
This extract targets inflammatory pathways by inhibiting the release of inflammatory mediators and specifically downregulating JAK/STAT signaling (JAK1/2 and STAT1/3 phosphorylation). Its antioxidant capabilities stem from its ability to neutralize free radicals, thereby reducing oxidative cellular destruction and decelerating intrinsic aging processes. Furthermore, it modulates the immune response by promoting lymphocyte activation and proliferation, and demonstrates anti-allergic effects through significant inhibition of eosinophil and mast cell activation, alongside reducing histamine levels and modulating the Th2-IgE-mast cell immune axis. Its constituents, including polyphenols, flavonoids, and triterpenoids, also confer anti-microbial action and support cell renewal via the Wnt/β-catenin, ERK, and JNK signaling pathways.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal stability and suitability for topical application have been observed in formulated gels within a pH range of 6.7 to 7.0, aligning closely with physiological skin pH.
Safety
Safety Profile
While generally regarded as safe with good tolerance for internal medicinal applications, internal consumption has been linked to gastrointestinal discomforts such as nausea, abdominal pain, and burning sensations. However, in vivo studies evaluating its medicinal use noted no significant irritation to nasal mucosa or major organs, suggesting a low topical irritation potential.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Centipeda Minima Extract is a valuable ingredient for precision skincare, offering broad benefits in reducing inflammation, combating oxidative stress, and promoting skin regeneration, with demonstrated compatibility across all skin types.
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References
Sources