Science
Mechanism of Action
Centipeda Cunninghamii Extract exerts its profound effects through a synergistic blend of actions. It robustly mitigates inflammation by targeting key inflammatory mediators such as PGE2 COX, nitric oxide (NO), and TNF-α, thereby reducing visible redness and discomfort. Its rich complex of flavonoids, terpenoids, and novel caffeoyl esters provides superior antioxidant defense, shielding the skin from UV-induced damage and free radical stress. Furthermore, the extract actively stimulates collagen synthesis and accelerates cellular regeneration, leading to improved skin elasticity, reduced appearance of fine lines, and overall enhanced skin texture and resilience.
Research
Clinical Evidence
High confidence2.5%
Key findings
- 01 Clinical evaluations have established significant topical anti-inflammatory, antihistaminic, and cell renewal properties, with specific active components showing efficacy at 0.2%.
- 02 Formulations incorporating Centipeda Cunninghamii Extract between 1.0% and 5.0%, with a preference for 2.0% to 3.0%, have proven effective in managing various dermatological conditions, including eczema, psoriasis, and acne.
- 03 The proprietary Cehami® variant, a Centipeda Cunninghamii extract, is successfully integrated into cosmetic and skincare products at concentrations from 0.3% for toners up to 20% for more intensive applications, demonstrating its potent anti-inflammatory, regenerative, and moderate UV protection attributes.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal extraction of Centipeda Cunninghamii should minimize heat exposure, ideally occurring below 60°C under reduced pressure, to preserve its volatile active compounds. The resulting aqueous-alcoholic extract is readily soluble in water and various ethanol concentrations, facilitating broad formulation versatility. Preservation with common agents like methyl/propyl hydroxybenzoate or ethanol is recommended to maintain extract integrity.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not yet assessed Centipeda Cunninghamii Extract. Comprehensive safety data, including GHS classifications and specific toxicity profiles for oral, dermal, or inhalation routes, are currently unavailable from sources like The Good Scents Company. While a formal FDA cosmetic status is pending, the general low systemic toxicity implied by 'generally recognized as safe' (GRAS) considerations for certain plant extracts in food may suggest a similar profile for topical cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Centipeda Cunninghamii Extract is a highly valuable botanical ingredient, clinically demonstrated to provide significant anti-inflammatory, antioxidant, and cell regenerating benefits, making it an exceptional choice for diverse skin concerns and overall skin optimization.
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