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CENTELLA ASIATICA MERISTEM CELL CULTURE.

Valuable CAS 84696-21-9 / ANTIOXIDANT, SKIN PROTECTING

Centella Asiatica Meristem Cell Culture utilizes the inherent regenerative capabilities of plant stem cells to deliver multifaceted skin benefits. This precisely cultivated ingredient actively provides antioxidant defense, fortifies the skin's natural barrier, and supports profound hydration, culminating in enhanced skin resilience and overall health.

Summary

Antioxidant Skin Protecting Anti-inflammatory Hydrating Skin Barrier Support Collagen Boosting Wound Healing

Science

Mechanism of Action

This advanced ingredient exerts its effects by significantly promoting fibroblast proliferation, which is critical for elevating the synthesis of collagen and intracellular fibronectin. These actions collectively enhance the tensile strength of new skin tissue, aiding in wound healing and scar reduction. Key active compounds, including asiaticoside, madecassoside, asiatic acid, and madecassic acid, directly stimulate Type I collagen production and angiogenesis. Madecassoside specifically diminishes cytokine-induced inflammation and offers protection against UV-induced skin aging. Furthermore, Centellosides within the culture stimulate the production of glycosaminoglycans (GAGs), such as hyaluronic acid, which are vital for maintaining skin moisture and volume. Overall, it functions as a potent antioxidant, anti-inflammatory, and skin-protecting agent, fundamentally improving hydration and fortifying the skin barrier.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A moisturizing fluid containing Centella asiatica stem cell extract, combined with 1% hyaluronic acid and 5% glycerin, was clinically observed to significantly improve skin hydration for up to 24 hours and enhance skin barrier function in healthy subjects. The specific extract concentration within the fluid was not quantified.
  2. 02 In vitro analysis of Centella asiatica extracellular vesicles (EVs) derived from tissue culture demonstrated dose-dependent antioxidant activity, achieving 74.5% ± 0.39% scavenging activity at a concentration of 2 x 10^7 particles/mL.

Transparency

Dusting Analysis

Not commonly dusted

Given its demonstrated benefits in hydration, barrier support, and cellular regeneration, Centella Asiatica Meristem Cell Culture is considered a high-performance active ingredient, making it an unlikely candidate for cosmetic dusting.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 7.5
0 7 14

Stability

Optimal stability is typically maintained within a pH range of 4.5 to 7.5. For the cellular components, plant tissue culture studies suggest stability around pH 5.8.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
6%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Centella Asiatica Meristem Cell Culture is safe for cosmetic use as currently practiced, provided formulations are non-sensitizing. A human repeated insult patch test, evaluating the ingredient at an effective concentration of 6% in distilled water (derived from a 20% glycerol solution), showed no evidence of skin irritation or allergic contact dermatitis. It has also been classified as non-phototoxic.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Centella Asiatica Meristem Cell Culture is a valuable ingredient, scientifically recognized for its ability to bolster hydration, reinforce the skin barrier, provide antioxidant protection, and facilitate skin repair across diverse skin types.

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