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CENTELLA ASIATICA FLOWER/LEAF/STEM EXTRACT.

Valuable CAS 84696-21-9 / SKIN CONDITIONING

A botanical powerhouse, Centella Asiatica Flower/Leaf/Stem Extract is celebrated for its multifaceted benefits, including robust collagen synthesis, potent anti-inflammatory action, and significant antioxidant protection. It actively promotes skin healing, enhances hydration, and supports barrier function for healthier, more resilient skin.

Summary

Skin Conditioning Soothing Wound Healing Anti-inflammatory Antioxidant Moisturizing Stimulates GAGs & Hyaluronic Acid Synthesis Enhances Collagen Synthesis Anti-aging

Science

Mechanism of Action

This extract operates by stimulating fibroblast proliferation, which is critical for increasing collagen and intracellular fibronectin content, thereby boosting the skin's tensile strength and aiding in wound repair. Its anti-inflammatory properties are key in mitigating irritation and preventing scar formation. Furthermore, it elevates antioxidant levels to defend against free radical damage, improves localized blood supply, and enhances skin hydration through the stimulation of glycosaminoglycans, notably hyaluronic acid.

Research

Clinical Evidence

High confidence
Effective range 0.2–5%
Optimal

5%

Key findings

  1. 01 An emulsion or hydrogel formulated with 5% Centella Asiatica extract delivered pronounced moisturizing and anti-inflammatory benefits, resulting in a 12% increase in skin hydration after daily application.
  2. 02 Asiaticoside, a key active component within Centella Asiatica, was shown to effectively increase antioxidant levels in rat skin when applied at a 0.2% concentration.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.2%
Red flag below
1%

While specific compounds demonstrate antioxidant benefits at 0.2%, significant overall moisturizing and anti-inflammatory effects are typically observed at higher concentrations, such as 5%. Products formulated below 0.2% may not yield discernible results. Conversely, concentrations exceeding 1% have been associated with sensitization in certain individuals, despite a high general irritancy threshold, necessitating careful formulation considerations.

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Optimal stability is achieved within a pH range of 4.0 to 7.0.

Conflicts

  • strong acids
  • high concentrations of Vitamin C
  • certain essential oils

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.5%
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Centella Asiatica Flower/Leaf/Stem Extract is safe for use in cosmetics. It is commonly reported in leave-on facial products at concentrations up to 0.5%. While the irritancy threshold is greater than 30%, indicating low general irritation potential, human patch tests have shown positive reactions at concentrations as low as 1% in susceptible individuals, and a 30% concentration was classified as a weak sensitizer in guinea pig studies. Formulators should consider these factors when exceeding the typical 0.5% usage.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Centella Asiatica Flower/Leaf/Stem Extract is a valuable ingredient, universally compatible with all skin types, offering significant benefits in soothing, healing, collagen stimulation, and hydration, making it ideal for comprehensive skin barrier support and anti-aging formulations.

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