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Moumoujus

CENTELLA ASIATICA CALLUS EXTRACT.

Valuable / ANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN PROTECTING

Moumoujus ingredient Centella Asiatica Callus Extract is a powerhouse botanical derivative engineered for comprehensive skin rejuvenation. It actively promotes cellular repair, enhances collagen synthesis, and provides potent antioxidant protection. This extract is designed to foster a resilient, youthful, and calm complexion.

Summary

skin conditioning antioxidant skin protecting collagen boosting soothing hydrating wound healing anti-aging scar reduction barrier strengthening

Science

Mechanism of Action

Centella Asiatica Callus Extract operates on multiple cellular pathways to improve skin health and appearance. It stimulates the proliferation of dermal fibroblasts, critical for generating skin's structural proteins, and significantly boosts the production of collagen types I and III, along with intracellular fibronectin, enhancing skin's tensile strength. The extract also activates the synthesis of glycosaminoglycans, notably hyaluronic acid, which is key for maintaining skin elasticity and hydration. Its anti-inflammatory properties help mitigate hypertrophic scarring and keloid formation. Furthermore, it fortifies the skin barrier through ceramide production and delivers robust antioxidant protection by upregulating cellular antioxidant enzymes (CAT, GPx1, SOD1) and inhibiting MMP-9, thereby safeguarding against oxidative stress and premature aging. These actions collectively lead to improved skin regeneration, reduced redness, and minimized scarring.

Research

Clinical Evidence

Medium confidence
Effective range 15–60%
Optimal

N/A

Key findings

  1. 01 In-vitro studies utilizing concentrations from 15-60 µg/mL demonstrated preventive activities against H2O2-induced cytotoxicity in human dermal fibroblasts, achieved by upregulating cellular antioxidant machinery (CAT, GPx1, SOD1) and suppressing MMP-9 activity.
  2. 02 Methanolic extracts of callus cultures exhibited an IC50 of 273 ± 14.14 µg/mL in a DPPH assay, signifying high in-vitro antioxidant potential.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific optimal pH range for stability is not detailed. However, active constituents (madecassoside, asiaticoside) derived from Centella asiatica show instability when stored at 25°C and 40°C, but maintain stability at 4°C. General Centella asiatica extract is partially soluble in hot water, and hydrophobic compounds may require solubilizing agents like Polysorbate 80 for optimal dispersion in aqueous formulations.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Centella asiatica callus culture, alongside other Centella asiatica-derived ingredients, is safe for use in cosmetic products under current practices and concentrations, provided the final formulation is non-sensitizing. The maximum reported use concentration for related Centella asiatica extracts is up to 0.5% in face and neck products (excluding sprays). While general Centella asiatica extract has been categorized as a weak sensitizer in some studies, its raw extract and triterpenic constituents are considered very weak sensitizers, suggesting a low overall risk.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Centella Asiatica Callus Extract is a valuable multi-functional ingredient that enhances skin regeneration, provides significant antioxidant protection, and boosts structural protein synthesis for a firmer, calmer, and more resilient complexion.

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