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Moumoujus

CENTELLA ASIATICA CALLUS CULTURE LYSATE.

Valuable / SKIN CONDITIONING

This advanced botanical ingredient, derived from Centella Asiatica plant cell culture, is a powerhouse for skin regeneration and rejuvenation. It actively stimulates collagen production, provides robust antioxidant protection, and delivers comprehensive soothing and hydrating benefits to improve overall skin health and resilience.

Summary

Skin Conditioning Antioxidant Collagen Booster Anti-inflammatory Soothing Barrier Support Wound Healing Hydration

Science

Mechanism of Action

Centella Asiatica Callus Culture Lysate is rich in beneficial compounds including triterpenoids, flavonoids, and phenolic acids. Its mechanism involves a multi-pronged approach to skin health: 1. **Antioxidant Action**: It neutralizes free radicals, safeguarding skin cells from oxidative stress and mitigating visible signs of aging. 2. **Collagen and ECM Support**: It significantly promotes the synthesis of Type I and III collagen and stimulates fibroblast proliferation, enhancing skin elasticity and firmness. It also supports the production of glycosaminoglycans, such as hyaluronic acid, for improved hydration. 3. **Barrier Enhancement**: Strengthens the skin's protective barrier, aiding in moisture retention and defense against environmental aggressors. 4. **Soothing and Anti-inflammatory**: Reduces irritation, inflammation, and redness by inhibiting nitric oxide synthesis and key inflammatory enzymes like COX-2 and LOX. 5. **Skin Conditioning & Regeneration**: Improves skin texture, making it softer, smoother, and more hydrated. It also supports wound healing and skin regeneration, accelerating repair processes.

Research

Clinical Evidence

High confidence
Effective range 1–10%
Optimal

5%

Key findings

  1. 01 Stimulated collagen secretion in human dermal fibroblasts by 31% more than a negative control.
  2. 02 Stimulated collagen secretion in human dermal fibroblasts by 65% more than a negative control, representing 127% of positive control (TGF-β) stimulation.
  3. 03 Stimulated collagen secretion in human dermal fibroblasts by 42% more than a negative control, achieving 80% of positive control (TGF-β) stimulation.

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest this ingredient is commonly used at ineffective 'dusting' percentages in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While specific optimal pH for its stability in a finished cosmetic product is not readily available, the pH of its callus culture media is typically maintained around 5.7±0.1 during cultivation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) explicitly stated that safety test data for 'Centella asiatica callus culture' was not included in its 2015 assessment of Centella asiatica-derived ingredients. Generally considered safe for topical use, it rarely induces allergic reactions or skin irritation. However, while uncommon, potential side effects such as redness, itching, or allergic contact dermatitis have been noted, particularly with higher-than-recommended doses of its triterpene compounds.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Low

Our Assessment

Verdict

Valuable

Centella Asiatica Callus Culture Lysate is a valuable ingredient, demonstrating potent collagen-stimulating, antioxidant, and anti-inflammatory properties crucial for advanced skin repair and rejuvenation.

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