Science
Mechanism of Action
This extract stimulates fibroblast proliferation and enhances the synthesis of Type I and III collagen, crucial for improving skin tensile strength and facilitating wound repair. It also boosts the production of glycosaminoglycans, including hyaluronic acid, significantly improving skin hydration. Its anti-inflammatory action involves inhibiting various inflammatory pathways and reducing pro-inflammatory cytokines like PGE2, IL-1β, IL-6, and TNFα, alongside moderating COX-2 and LOX activity. Furthermore, it offers antioxidant protection by neutralizing free radicals and preventing lipid peroxidation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated significant improvements in skin firmness, elasticity, and hydration over six months in women aged 45-60 with photoaged skin.
- 02 An emulsion containing this concentration showed protective skin effects, reducing erythema and trans-epidermal water loss (TEWL), and increasing skin hydration by 12% with daily use.
Transparency
Dusting Analysis
While specific efficacy data for Centella Asiatica Adventitious Root Extract at its recommended maximum safe concentration of 0.1% (solid content) is primarily focused on safety, a key active compound of Centella (madecassoside) shows efficacy at 0.1%. General Centella extract demonstrates benefits at 5%. This suggests that for broader benefits, higher concentrations of the overall extract or specific active standardization might be required, making precise formulation crucial to avoid potential 'dusting' if only minimal amounts are included.
The Formula
Formulation
Stability
The adventitious root induction process maintains a pH of 5.8 ± 0.1, suggesting this range is favorable for its biological activity. However, specific stability data for this extract within diverse cosmetic formulations is not extensively detailed.
Synergies
- Vitamin C (demonstrated enhanced anti-aging benefits when combined with madecassoside)
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has deemed Centella asiatica root extract safe at concentrations and uses currently practiced in cosmetics, provided formulations are non-sensitizing. Specifically, a 0.1% solid content of the root extract showed no dermal irritation or allergic sensitization in patch testing. It's noted that general Centella asiatica extract was classified as a weak sensitizer at a very high concentration (30%) in one study, but this is not directly applicable to the root extract at common cosmetic concentrations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Centella Asiatica Adventitious Root Extract is a valuable ingredient, offering broad benefits from anti-aging and hydration to soothing and barrier support, with a low irritancy risk for all skin types within safe concentrations.
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References
Sources