Science
Mechanism of Action
This extract exerts its primary benefits through strong antioxidant action, attributed to phenolic compounds like chlorogenic acid and gallic acid. These compounds neutralize free radicals, reduce oxidative stress, and upregulate endogenous antioxidant genes. Its anti-inflammatory effects stem from components such as isoquercitrin, which inhibits pro-inflammatory cytokines. Furthermore, the flavonols present in the extract stimulate keratinocyte proliferation and migration, facilitating skin repair and maintaining overall dermatoprotective qualities.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 An ointment formulation containing the extract demonstrated significant antioxidant activity, achieving 58% DPPH inhibition for the extract alone.
- 02 An aqueous extract at 50 μg/mL exhibited 25.25 ± 0.72% DPPH radical scavenging activity.
- 03 At 400 μg/mL, the aqueous extract showed 32.23 ± 0.93% lipoperoxidation inhibition, safeguarding cellular lipids.
- 04 The extract's flavonols stimulate the proliferation and migration of keratinocytes, contributing to tissue repair.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While certain constituents like gentiopicroside and sweroside may show degradation at high temperatures and after six months of storage, xanthones within the extract exhibit robust stability. It has been successfully incorporated into ointment formulations designed to maintain physiological pH for optimal skin application.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not reviewed this ingredient. While Incidecoder indicates low irritancy and comedogenicity, the EMA report on oral traditional herbal medicinal products mentions potential risks of 'allergic skin reactions' and 'digestive disorders'. Acute and subchronic oral toxicity studies in mice showed no observed adverse effect levels (NOAEL) at high doses of 15 g/kg and 1200 mg/kg for 90 days, respectively.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Centaurium erythraea extract is a valuable botanical ingredient, offering comprehensive antioxidant, anti-inflammatory, and skin-conditioning benefits, making it highly suitable for diverse skin types and precision formulations.
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