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Moumoujus

CELASTRUS ORBICULATUS BRANCH/LEAF EXTRACT.

Insufficient Data CAS - / ANTIOXIDANT, BLEACHING

Derived from the branches and leaves of the Celastrus orbiculatus plant, this extract demonstrates a range of biological activities including antioxidant, anti-inflammatory, and antimicrobial properties. Its potential benefits for skin are suggested by its molecular mechanisms and in vitro studies, although direct clinical evidence on human skin is limited.

Summary

Antioxidant Soothing Astringent Anti-inflammatory Antimicrobial

Science

Mechanism of Action

This extract operates through multiple pathways to potentially benefit the skin. Its anti-inflammatory action is primarily attributed to celastrol, which inhibits the NF-κB pathway, a key regulator of inflammatory responses. It also suppresses the activity and expression of MMP-9, reducing invasion, and inhibits pro-inflammatory cytokines such as IL-1β and TNF-α. As an antioxidant, it actively scavenges free radicals, protecting cellular components from oxidative stress. Furthermore, specific methanolic extracts exhibit antimicrobial effects against bacteria like B. subtilis, P. vulgaris, and S. marcescens.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies using ethyl acetate extract (COE) showed dose-dependent inhibition of gastric cancer stem cell spheroid formation and reduction of specific cell subpopulations (CD44+/CD24+, ALDH+).
  2. 02 Concentration-dependent inhibition of proliferation and promotion of apoptosis were observed in human Burkitt lymphoma cells treated with Celastrus orbiculatus extract.
  3. 03 COE suppressed the invasion of fibroblast-like synoviocytes (FLSs) stimulated by IL-1β and TNF-α, by inhibiting MMP-9 expression and NF-κB activation, indicating anti-inflammatory potential.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

The method of extraction has been observed to influence the thermal stability of Celastrus orbiculatus.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

There is currently no specific safety evaluation status from regulatory bodies such as CIR, SCCS, or FDA for CELASTRUS ORBICULATUS BRANCH/LEAF EXTRACT. Available data indicates its safety profile is 'Not rated' or has 'No data available', necessitating further research for comprehensive risk assessment.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While CELASTRUS ORBICULATUS BRANCH/LEAF EXTRACT exhibits promising in vitro antioxidant, anti-inflammatory, and antimicrobial mechanisms, a critical lack of specific skin clinical efficacy data, optimal concentrations, and comprehensive safety assessments prevents a conclusive recommendation for precision skincare.

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