Science
Mechanism of Action
This extract primarily operates through its robust antioxidant, anti-inflammatory, and antibacterial actions. It effectively counteracts oxidative stress by inhibiting Reactive Oxygen Species (ROS) generation and mitigating mitochondrial dysfunction. Its anti-inflammatory prowess stems from suppressing nitric oxide (NO) production in LPS-stimulated macrophage cells (RAW 264.7) and reducing inflammation in P. acnes-treated keratinocytes (HaCaT cells), a process regulated by the inhibition of MAPK pathways. Furthermore, it demonstrates direct antibacterial activity, notably against P. acnes, and contributes to skin hydration.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
Information regarding 'dusting' behavior or specific thresholds for this ingredient was not available in the provided research data.
The Formula
Formulation
Stability
No specific optimal pH range for stability in cosmetic formulations was documented. However, its extractability using both aqueous and organic solvents suggests a broad chemical profile, allowing for versatile incorporation into various formulation types.
Safety
Safety Profile
While comprehensive safety assessments by regulatory bodies such as CIR or SCCS are not yet available, existing reports generally characterize Toona sinensis, a synonym for this extract, as having low toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
With its scientifically supported antioxidant, anti-inflammatory, and antibacterial activities, Cedrela Sinensis Leaf Extract is a valuable botanical ingredient poised to address multiple skin concerns, particularly for stressed, blemish-prone, or environmentally exposed skin.
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References
Sources