Science
Mechanism of Action
This extract functions as a multi-pathway modulator; it inhibits the expression of inducible nitric oxide synthase (iNOS) by up to 98% and cyclooxygenase-2 (COX-2) by approximately 49%. By suppressing these pro-inflammatory enzymes, it reduces the production of inflammatory mediators while utilizing its flavonoid profile—including vicenin-2 and isovitexin—to scavenge free radicals.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 In vivo models demonstrated a 66% reduction in acute edema and a 37% inhibition of subchronic inflammation.
- 02 In vitro macrophage testing showed a 98% inhibition of iNOS expression at 22.3 µg/mL.
- 03 Antioxidant IC50 was identified at 153.97 µg/mL in DPPH scavenging assays.
Transparency
Dusting Analysis
Due to its efficacy in micro-gram concentrations during lab trials, many formulations include it at 'label-claim' levels (below 0.05%) which may not provide the full anti-inflammatory benefits observed in clinical data.
The Formula
Formulation
Stability
Highly heat-sensitive due to flavonoid content; must be incorporated during the cool-down phase at temperatures below 40°C.
Synergies
- Vitamin E
- Soothing agents like Bisabolol
- Hyaluronic acid
Conflicts
- Strong oxidizing agents
- Extreme pH environments
Safety
Safety Profile
Historically used in traditional medicine with a long-standing safety profile for topical application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance botanical extract that provides clinically backed inflammatory modulation and antioxidant protection for all skin types.
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References
Sources