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CARTHAMUS TINCTORIUS FLOWER EXTRACT.

Valuable CAS 223749-52-8 / SKIN CONDITIONING

Commonly known as Safflower, this botanical extract is a multi-functional phyto-active rich in flavonoids like hydroxysafflor yellow A. It serves as a precision tool for addressing oxidative stress, uneven skin tone, and the degradation of the dermal matrix.

antioxidant soothing skin brightening matrix protection humectant

Science

It functions through a triple-action pathway: suppressing tyrosinase activity to inhibit melanin synthesis, neutralizing free radicals to prevent UV-induced oxidative damage, and inhibiting collagenase and elastase enzymes to maintain structural integrity. Furthermore, it modulates the NF-kB signaling pathway to reduce pro-inflammatory cytokine production.


Research

High confidence
Effective range 0.4–5%
Optimal

2.5%

Key findings

  1. 01 Demonstrated significant reduction in melanin production in B16F10 melanoma cells at a 0.4% concentration.
  2. 02 Proven to shield human cells from H2O2-induced oxidative stress at concentrations as low as 2-10 µg/mL.
  3. 03 Formulation benchmarks indicate a 2% to 5% range is necessary for comprehensive anti-aging and moisturizing benefits.

Transparency

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

While it shows bioactivity at very low levels (0.4%) for brightening, many anti-aging claims require 2% or more. Products listing it near the bottom of the INCI list often fail to meet the therapeutic threshold for structural skin repair.


The Formula

Solubility
Water
Optimal pH 3.9 – 7.2
0 7 14

Stability

Highly pH-sensitive; the extract transitions from a greenish-yellow hue to an orange-red shade when pH exceeds 7.0.

Synergies

  • Vitamin C
  • Niacinamide
  • Hyaluronic Acid

Conflicts

  • Strong oxidizing agents
  • Extreme pH environments (<3.5 or >9.0)

Safety

CIR Status
Safe as used
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

Topical application is considered safe and non-toxic. While extreme oral doses in animal models raised reproductive concerns, these are not applicable to the concentrations and delivery methods used in skincare.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A sophisticated botanical active that provides robust antioxidant defense and brightening efficacy when formulated within its stability window.


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