Science
Mechanism of Action
This extract functions by stimulating the PI3K/Akt and Wnt/β-catenin signaling pathways, which are vital for cellular proliferation and tissue regeneration. It further induces autophagy by increasing LC3I/II ratios and optimizes the cell cycle by modulating proteins such as cyclin D1 and cdc2 p34, effectively promoting epithelial vitality and barrier conditioning.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Activation of the anagen pathway via Wnt/β-catenin and phospho-Akt upregulation in dermal papilla cells (Kang et al., 2021).
- 02 Significant antioxidant activity and promotion of epithelial cell proliferation in in vitro models (Kim et al., 2023).
Transparency
Dusting Analysis
Because this extract demonstrates cellular activity at extremely low concentrations (as low as 0.1 μg/mL), it is highly effective even in small doses, making it less susceptible to 'label dusting' compared to standard botanical fillers.
The Formula
Formulation
Stability
Maintains peak stability within a slightly acidic range; typically formulated alongside glycerin or glycols to ensure long-term botanical integrity.
Synergies
- Glycerin
- Antioxidants
- PI3K pathway activators
Safety
Safety Profile
Recognized by the European Commission's CosIng database; while specific CIR safety assessments are pending, it is currently classified as a low-irritancy botanical.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated botanical extract that offers scientifically-backed benefits for both hair follicle activation and cellular skin protection.
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References
Sources