Science
Mechanism of Action
This high-affinity protein functions through thiol-disulfide exchange, establishing new chemical bonds with damaged keratin within the stratum corneum. Beyond surface protection, it promotes fibroblast proliferation and re-epithelialization, facilitating the biological regeneration of compromised tissue.
Research
Clinical Evidence
High confidence4.5%
Key findings
- 01 Demonstrated structural repair and heat-induced gelation at concentrations as low as 0.8% (Biomacromolecules, 2013).
- 02 Observed significant fibroblast proliferation and wound healing support at a 4.5% concentration (Journal of Biomedical Materials Research, 2015).
Transparency
Dusting Analysis
Many products include keratin derivatives for label appeal at negligible levels; however, this specific disulfide variant requires at least 0.8% to initiate chemical bonding and structural repair. Concentrations below this threshold are unlikely to provide functional restorative benefits.
The Formula
Formulation
Stability
The molecule is sensitive to acidic environments; at pH levels below 5.5, it may lose solubility and precipitate. Formulating in acidic ranges requires specialized ionic surfactants for stabilization.
Synergies
- Ionic surfactants (for stability)
- Mild cleansing agents
- Humectants
Conflicts
- Strong oxidizing agents
- Low pH environments (< 5.0)
Safety
Safety Profile
Confirmed as biocompatible and non-sensitizing in the 2021 CIR safety assessment for both leave-on and rinse-off applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated, biocompatible protein that provides genuine structural reinforcement and cellular support for damaged or aging skin barriers.
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