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CAPSICUM ANNUUM LEAF EXTRACT.

Valuable CAS 84625-29-6 / SKIN CONDITIONING

Derived from the leaves of the Red Pepper plant, this botanical extract is a potent source of polyphenols and essential minerals designed to revitalize dull skin. It serves as a multifunctional bio-active that restores radiance while reinforcing the skin’s natural defenses against environmental stressors.

Skin conditioning Antioxidant Anti-inflammatory Brightening

Science

The extract operates through a high concentration of flavonoids and phenolic compounds that neutralize free radicals via electron donation. It simultaneously modulates the inflammatory response by downregulating key cytokines like IL-1α and TNF-α, while its mineral content supports osmotic balance and barrier hydration.


Research

Medium confidence
Effective range 0.5–80%
Optimal

0.5%

Key findings

  1. 01 In vivo testing at 0.5% in a specialized blend confirmed significant improvements in skin homogeneity and a visible reduction in signs of fatigue around the periorbital area.
  2. 02 A 4-week clinical trial involving 30 subjects demonstrated that aqueous leaf extracts significantly enhance complexion radiance and tone uniformity.
  3. 03 In vitro assays verified broad-spectrum antimicrobial activity against S. aureus at concentrations between 50-200 mg/ml.

Transparency

Commonly dusted
Min. effective
0.5%
Red flag below
0.05%

While many brands claim 'Red Pepper' benefits, they often include it at negligible levels for marketing. Clinical efficacy for radiance is documented at 0.5%; concentrations significantly below this likely provide only basic antioxidant support rather than visible brightening.


The Formula

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Highly stable in water-based systems, especially when stabilized with humectants like glycerin to improve molecular delivery and shelf life.

Synergies

  • Glycerin
  • Vitamin C
  • Niacinamide

Conflicts

  • Strong oxidizing agents
  • Highly alkaline formulations (pH > 8.0)

Safety

CIR Status
Safe as used
Max tested
0.5%
Pregnancy
Safe
Sensitization risk Low

Extensive patch testing (HRIPT) on over 100 subjects showed zero evidence of irritation, even at concentrated levels. It is recognized as a non-sensitizing botanical.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An excellent botanical for targeting skin fatigue and oxidative stress, particularly effective for brightening the delicate eye area when used at a 0.5% threshold.


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References