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CAPRYLYL BUTYRATE.

Valuable CAS 110-39-4 / FRAGRANCE, PERFUMING, SKIN CONDITIONING

A multifunctional postbiotic ester that functions as both a high-performance emollient and a biological signaling molecule. It is unique for its ability to deliver short-chain fatty acids directly to the skin's surface, supporting both barrier integrity and cellular health.

Skin conditioning Emollient Postbiotic precursor Fragrance component Solvent

Science

Upon application, skin esterases hydrolyze this ester into octanol and butyric acid. The resulting butyrate acts as a postbiotic and histone deacetylase (HDAC) inhibitor, which suppresses inflammatory cytokines and stimulates regulatory T cells to accelerate wound healing and revitalize hair follicle activity.


Research

High confidence
Effective range ≤38.8%
Optimal

N/A

Key findings

  1. 01 A 4-month double-blind, placebo-controlled study demonstrated that formulas containing Caprylyl Butyrate achieved 100% positive hair growth results, specifically increasing the anagen/telogen ratio by 46%.
  2. 02 Safety evaluations of related alkyl esters confirmed a lack of sensitization or irritation even at concentrations as high as 38.8%.

Transparency

Not commonly dusted

Caprylyl Butyrate is not currently a 'marketing' buzzword, meaning it is typically included for its functional emollient or active postbiotic properties rather than for label-claim 'dusting'.


The Formula

Solubility
Oil
Optimal pH 4 – 7
0 7 14

Stability

Highly stable under standard storage conditions, though it may undergo premature hydrolysis into its constituent acid and alcohol if exposed to extremely high or low pH levels.

Synergies

  • Lipophilic active delivery systems
  • Hair growth stimulants (e.g., Minoxidil or peptide complexes)
  • Barrier-repairing lipids

Conflicts

  • Strong oxidizing agents
  • Highly acidic formulations (pH <4.0)
  • Highly alkaline formulations (pH >7.0)

Safety

CIR Status
Safe as used
Pregnancy
Safe
Sensitization risk Low

Recognized by the FDA as a GRAS (Generally Recognized as Safe) flavoring agent, reinforcing its low toxicological profile.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An exceptional multi-tasking ester that provides low-irritancy emolliency while offering scientifically-backed benefits for hair density and inflammatory skin modulation.


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