Science
Mechanism of Action
This peptide targets the CD44 cell-surface glycoprotein, the primary receptor for hyaluronic acid, to enhance cellular communication and barrier function. By inhibiting lipogenesis within sebocytes, it effectively reduces excess oil at the source while providing antimicrobial defense against C. acnes and neutralizing oxidative stress.
Research
Clinical Evidence
High confidence2.5%
Key findings
- 01 In vivo testing demonstrated a visible reduction in surface sebum of up to 38% over a 28-day period of consistent application.
Transparency
Dusting Analysis
Because this is a specialized peptide often supplied in a diluted solution, concentrations below 1% of that solution are unlikely to trigger the significant anti-sebum effects observed in clinical data.
The Formula
Formulation
Stability
Heat-sensitive; must be incorporated during the cooling phase of production (below 40°C). Stable between pH 4 and 8, though 5-7 is optimal for peptide structure.
Synergies
- Hyaluronic Acid
- Niacinamide
- Zinc PCA
Conflicts
- Strong oxidizing agents
- Extreme pH environments
- High thermal processing
Safety
Safety Profile
Recognized by the EU CosIng database as safe for cosmetic application; its high molecular weight limits deep systemic penetration, reducing irritation risk.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional precision ingredient for controlling oil and supporting skin longevity without the irritation common in traditional acne actives.
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References
Sources