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CAPRYLOYL SH-NONAPEPTIDE-6.

Valuable / SKIN CONDITIONING

A bio-engineered, lipid-conjugated peptide engineered to arrest 'inflammaging' at the cellular level. By merging a nonapeptide sequence with a capryloyl group, this active achieves superior skin penetration to modulate immune-driven aging processes.

Anti-inflammatory Cell-communicating Skin conditioning Anti-aging

Science

Functions as a cell-communicating agent that specifically balances the Th17 immune pathway. It inhibits the expression of pro-inflammatory cytokines like IL-17, neutralizing the damaging effects of UV radiation and PM2.5 pollution before they can trigger collagen degradation.


Research

High confidence
Effective range 1–5%
Optimal

3%

Key findings

  1. 01 In vivo clinical trials demonstrated a 34.5% overall improvement in periorbital wrinkles after 4 weeks of use.
  2. 02 Targeted measurements showed an 11% reduction in deep wrinkle depth and a 14% reduction in fine eyelid lines.
  3. 03 In vitro data confirms significant suppression of IL-17, the primary mediator of environmental skin inflammation.

Transparency

Not commonly dusted
Min. effective
1%
Red flag below
0.5%

As a specialized recombinant peptide, it is frequently used at concentrations below 1% in mass-market formulations for label claims. Moumoujus standards require at least 1% of the active solution to mirror clinical success in wrinkle reduction.


The Formula

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

The capryloyl modification enhances lipophilicity and penetration. The molecule is stable at room temperature but is vulnerable to degradation by proteolytic enzymes and extreme thermal stress.

Synergies

  • Hyaluronic Acid
  • Niacinamide
  • Non-proteolytic peptides

Conflicts

  • Proteolytic enzymes (Papain, Bromelain)
  • Strong oxidizing agents
  • Extreme pH environments (<3.0 or >9.0)

Safety

CIR Status
Not reviewed
Sensitization risk Low

Human patch testing confirms it is non-irritating. Recognized by the EU Cosmetic Ingredient Glossary since 2022.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An advanced bio-mimetic peptide that offers a dual-action approach by soothing immune-related inflammation while clinically reducing wrinkle depth.


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