Science
Mechanism of Action
This peptide functions as an anti-inflammatory modulator by inhibiting the synthesis and expression of pro-inflammatory cytokines, including IL-1α, IL-8, and TNF-α. By targeting sensory receptors within keratinocytes, it desensitizes the skin to external triggers, effectively neutralizing the biochemical cascade that leads to stinging, pruritus, and UV-induced irritation.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Clinical evaluations demonstrate that a 2.0% concentration significantly reduces the expression of IL-1α and TNF-α while effectively suppressing skin itching caused by UV irradiation.
- 02 Research indicates an optimal efficacy window between 1.8% and 2.2% for maximizing neurosensory relief in hyper-reactive skin profiles.
Transparency
Dusting Analysis
As a specialized bio-active peptide, it is frequently included at 'label-claim' concentrations (often below 0.1%) rather than the 1.8%–2.2% range required to achieve the clinically proven neuro-calming and anti-inflammatory benefits.
The Formula
Formulation
Stability
Highly stable in aqueous systems when stabilized with glycols. To prevent thermal degradation of the peptide bonds, it must be incorporated during the cooling phase of production at temperatures below 40°C.
Synergies
- Glycerin
- Butylene Glycol
- Soothing botanicals
Conflicts
- Proteolytic enzymes
- Strong oxidizing agents
- Extreme pH environments (<3.0 or >8.0)
Safety
Safety Profile
Listed in REACH and IECIC inventories; documented as a non-irritating, safe cosmetic ingredient for long-term topical use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptionally effective peptide for inflammatory modulation and neurosensory relief when formulated at concentrations above 1.8%.
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References
Sources