Science
Mechanism of Action
This cell-communicating ingredient operates through a dual-action pathway: it activates the COL1A1 gene to stimulate the biosynthesis of Type I collagen while simultaneously suppressing MMP-1 enzymes, which are responsible for the enzymatic degradation of existing collagen fibers. The capryloyl attachment ensures superior lipophilicity, allowing the peptide to bypass the stratum corneum more efficiently than standard water-soluble peptides.
Research
Clinical Evidence
High confidence0.05%
Key findings
- 01 In vitro testing demonstrated a 38.44% increase in Type I collagen mRNA expression at a 0.05% concentration.
- 02 Clinical in vivo evaluations of peptide-infused formulations recorded a 16.2% improvement in facial lifting and a 5.5% increase in skin elasticity over 28 days.
Transparency
Dusting Analysis
Because peptides are effective at very low parts-per-million, brands often include them at 'label-claim' levels (below 0.01%) that lack the concentration necessary to trigger significant collagen synthesis. Look for transparent disclosures confirming at least 0.05% for clinical relevance.
The Formula
Formulation
Stability
Maintains structural integrity across a broad pH spectrum; however, it is thermolabile and should not be exposed to temperatures exceeding 45°C during manufacturing.
Synergies
- Hyaluronic Acid
- Vitamin C
- Niacinamide
- Other Signal Peptides
Conflicts
- Strong oxidizing agents
- Extreme pH environments (below 3.0 or above 9.0)
Safety
Safety Profile
Non-irritating and globally compliant with FDA and EU SCCS regulations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptionally bioavailable peptide that offers measurable improvements in dermal density and structural lifting when used at verified concentrations.
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References
Sources