Science
Mechanism of Action
This peptide functions by mimicking the activity of Elafin, a natural protease inhibitor. It communicates directly with skin cells to stimulate the synthesis of essential structural proteins, specifically Laminin-5, Collagen VII, and Fibronectin, which serve as the 'glue' for the Dermal-Epidermal Junction (DEJ) to ensure skin firmness and cohesion.
Research
Clinical Evidence
High confidence2.5%
Key findings
- 01 A 28-day clinical evaluation of the base peptide at 2.5% demonstrated a reduction in fine line and wrinkle depth by up to 29% through DEJ reinforcement.
- 02 Independent clinical testing on proprietary peptide blends containing this ingredient showed measurable improvements in barrier function, hydration, and skin texture within 4 weeks of consistent application.
Transparency
Dusting Analysis
Due to its high cost and efficacy at low levels, many mass-market products include this peptide at 'claim' levels (under 0.5%). For meaningful structural improvement and a reduction in wrinkle depth, concentrations should ideally align with the 2.5% clinical benchmark.
The Formula
Formulation
Stability
The C-terminus amide modification provides enhanced resistance against degradation by proteolytic enzymes. It is thermo-sensitive and must be incorporated during the cooling phase of production (below 40°C).
Synergies
- Hyaluronic acid
- Niacinamide
- Non-acidic antioxidants
Conflicts
- Strong oxidizing agents
- AHA/BHA formulations below pH 4.0
- Proteolytic enzymes (Papain, Bromelain)
Safety
Safety Profile
Classified as safe for cosmetic use with a low risk profile; it is non-sensitizing and generally well-tolerated by reactive skin types.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A precise, evidence-based peptide that delivers significant structural improvement and wrinkle reduction when formulated at clinical concentrations.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources