Science
Mechanism of Action
Operates through a dual-action pathway: it acts as a humectant by utilizing hydroxyl groups to bind water within the epidermis, while simultaneously modulating the NF-κB pathway. This biochemical intervention reduces the secretion of pro-inflammatory cytokines such as IL-6 and IL-8, effectively calming cutaneous stress and regulating lipid production.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 Application of 0.1%–1.0% concentrations demonstrated a 20–30% reduction in Transepidermal Water Loss (TEWL) compared to compromised skin controls.
- 02 Ultra-low concentrations of 0.005% showed superior inhibition of NF-κB activity and IL-8 secretion compared to purified CBD isolates.
- 03 In vitro testing at 20 μg/mL significantly suppressed the overproduction of MMP-1 enzymes and IL-6 induced by UVA irradiation, protecting Type I procollagen.
Transparency
Dusting Analysis
Due to the high marketing appeal of 'Cannabis' ingredients, this water is frequently used at negligible levels for label claims. While it shows anti-inflammatory activity as low as 0.005%, concentrations below 0.1% likely fail to provide the documented barrier-repair benefits.
The Formula
Formulation
Stability
Highly thermolabile; degradation of active constituents accelerates above 70°C. Requires protection from UV light and should be maintained in slightly acidic environments for maximum cannabinoid stability.
Synergies
- Hyaluronic Acid
- Niacinamide
- Centella Asiatica
Conflicts
- Strong oxidizing agents
- High processing heat
- Extreme pH levels (>8.0 or <3.0)
Safety
Safety Profile
In the EU, compliance with restriction II/306 is mandatory, ensuring the distillate is derived from non-prohibited parts of the plant and contains non-detectable psychotropic THC levels.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance soothing agent that outperforms CBD isolates in inflammatory modulation and provides measurable barrier support when formulated at 0.1% or higher.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources