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Moumoujus

CANNABIS SATIVA FLOWER/LEAF EXTRACT.

Valuable CAS 89958-21-4 (generic) / ANTI-SEBUM

A high-performance botanical extract derived from the aerial parts of the hemp plant, specifically targeted for its multi-functional ability to rebalance skin ecosystems. This precision ingredient excels at modulating lipid production and neutralizing inflammatory triggers, making it a cornerstone for both acne-prone and sensitive skin recovery.

Summary

soothing antioxidant sebum-regulating anti-inflammatory skin-conditioning

Science

Mechanism of Action

This extract operates through the cutaneous endocannabinoid system (ECS) by interfacing with CB1 and CB2 receptors. It actively suppresses the NF-κB signaling pathway to lower levels of pro-inflammatory cytokines such as IL-1β and TNFα. Furthermore, it inhibits lipogenesis in sebocytes to control oil output, provides antioxidant defense by upregulating superoxide dismutase, and protects the structural matrix by inhibiting enzymes like collagenase and elastase.

Research

Clinical Evidence

High confidence
Effective range 0.1–5%
Optimal

3%

Key findings

  1. 01 A 12-week clinical study utilizing a 3.0% concentration demonstrated significant reductions in both skin sebum production and visible erythema in patients with acne.
  2. 02 Phase 2 clinical data using a 5.0% solution showed a 40% decrease in both inflammatory and non-inflammatory acne lesions over 12 weeks.
  3. 03 In vitro analysis at 0.1% confirmed enhanced cell viability and robust protection against oxidative stress in human fibroblasts and keratinocytes.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
1%
Red flag below
0.1%

Due to its high cost and marketing appeal, many products include this extract at levels as low as 0.1% (marketing dusting). While 0.1% offers basic antioxidant protection, concentrations of 3.0% or higher are required to achieve the clinically validated anti-acne and sebum-regulating benefits.

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 7
0 7 14

Stability

Highly susceptible to degradation via UV light, heat, and oxidation. Exposure to temperatures exceeding 60°C or direct sunlight can convert active cannabinoids into Cannabinol (CBN), reducing efficacy.

Synergies

  • Squalane
  • Vitamin E (Tocopherol)
  • Linoleic Acid
  • Bisabolol

Conflicts

  • Strong oxidizing agents
  • High-temperature processing
  • Clear packaging (UV exposure)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Legally compliant extracts must contain <0.3% THC (US) or <0.2% THC (EU). The EU SCCS considers THC impurities safe in topical applications up to a threshold of 0.00025%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A sophisticated botanical powerhouse that offers scientifically backed solutions for inflammation and oil control when formulated at therapeutic concentrations.

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