Science
Mechanism of Action
This ingredient functions via the Microbiota-Skin-Brain Axis (MSBA) by stimulating skin flora to release a 'postbiotic cocktail.' This process triggers keratinocytes to produce cutaneous oxytocin, which then communicates with sensory neurons to reduce stress signals and boost local antioxidant defenses through the NRF2 pathway.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 fMRI imaging confirmed brain pleasure center activation within 15 minutes of use, reaching chocolate-consumption levels of stimulation by day 28.
- 02 Application of 2% concentration led to a 44% decrease in marionette line depth and a 27% reduction in frown line depth over 4 weeks.
- 03 At 1%, the ingredient successfully rebalanced the skin flora, increasing beneficial bacteria by 25% while reducing pathogens by 20%.
Transparency
Dusting Analysis
Because it is a high-cost 'neuro-cosmetic' ingredient, brands often include it at very low percentages (below 0.5%) for marketing claims. However, clinical data suggests 1-2% is necessary to achieve significant microbiome and anti-wrinkle results.
The Formula
Formulation
Stability
Thermolabile; must be incorporated during the cooling phase at temperatures below 40°C to maintain biological activity.
Synergies
- Hyaluronic Acid
- Niacinamide
- Probiotics
- Peptides
Conflicts
- High heat (>40°C)
- Strong oxidizing agents
Safety
Safety Profile
Certified 100% free of THC and CBD; non-psychoactive and COSMOS/Ecocert approved.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A cutting-edge neuro-cosmetic active that provides unique mood-boosting benefits and visible reduction in expression lines when used at 2%.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources