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CAMELLIA SINENSIS CALLUS CULTURE EXTRACT.

Valuable CAS 84650-60-2 / PERFUMING, SKIN CONDITIONING

A high-precision botanical stem cell extract derived from Green Tea that offers advanced cellular regeneration. Unlike standard extracts, this callus culture is bio-engineered to provide concentrated antioxidant protection and deep structural support for the dermal matrix.

Antioxidant Collagen Booster Anti-glycation Agent Skin Conditioning Anti-inflammatory

Science

This extract functions as a multi-dimensional skin protector by neutralizing Reactive Oxygen Species (ROS) and inhibiting MMP-2 collagenase enzymes that break down the skin's structural integrity. It simultaneously upregulates TIMP-1 to safeguard existing collagen fibers while activating NRF2 signaling pathways to enhance the skin’s innate antioxidant defense and DNA repair mechanisms against UV-induced damage.


Research

High confidence
Effective range 0.01–10%
Optimal

5%

Key findings

  1. 01 Clinical data indicates a 28.29% increase in collagen secretion and significant anti-glycation activity when used in concentrations up to 10%.
  2. 02 Research published in 2018 and 2025 confirms measurable improvements in skin hydration, barrier resilience, and elasticity at concentrations between 1% and 5%.

Transparency

Commonly dusted
Min. effective
1%
Red flag below
0.1%

While this ingredient is biologically active at very low levels (0.01%), the most significant clinical improvements in hydration and barrier function are observed at 1% or higher. Formulations using it below 0.1% are likely leveraging the 'stem cell' claim for marketing rather than physiological change.


The Formula

Solubility
Water
Optimal pH 4 – 7.5
0 7 14

Stability

Demonstrates excellent stability in aqueous solutions and O/W emulsions, though it should be protected from extreme heat and UV light to prevent phenolic degradation.

Synergies

  • UV filters
  • Hyaluronic acid
  • Niacinamide

Conflicts

  • Strong oxidizing agents
  • Ferric salts
  • High-concentration ethanol

Safety

CIR Status
Insufficient data (2014); recent 2025 validation shows 0.00 irritation index
Max tested
10%
Pregnancy
Safe
Sensitization risk Low

While historical CIR data was limited, modern clinical testing confirms a non-irritating profile. Note that IFRA limits usage to 0.052% only if the extract is utilized specifically as a fragrance component.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A sophisticated, non-irritating biotech ingredient that bridges the gap between botanical tradition and molecular skin repair.


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