Science
Mechanism of Action
It operates via the NRF2 signaling pathway to amplify the skin's internal antioxidant system. Rich in catechins like EGCG, it neutralizes reactive oxygen species, prevents the degradation of structural proteins by inhibiting collagenase and elastase, and suppresses inflammatory cytokines to fortify the epidermal barrier.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Demonstrated significant anti-inflammatory activity and disrupted the communication (quorum sensing) of acne-causing bacteria.
- 02 Upregulated filaggrin expression to enhance barrier function and accelerated wound-healing markers in clinical trials.
Transparency
Dusting Analysis
Because it is marketed as a 'stem cell' extract, brands often include it at symbolic levels (below 0.1%) for marketing claims. Efficacy for barrier repair and anti-inflammatory benefits requires a minimum of 0.5%.
The Formula
Formulation
Stability
Highly water-stable but sensitive to thermic degradation above 40°C and photo-oxidation. It may cause browning of the formula over time due to high polyphenol content.
Synergies
- Vitamin C
- Hyaluronic Acid
- Niacinamide
Conflicts
- Strong oxidizing agents
- Ferric salts
- High alkaline environments
Safety
Safety Profile
While CIR requested more data in 2019, clinical assessments show the extract is non-toxic and safe for topical use up to 2%, with industry standards allowing up to 5%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A potent biotechnological active that bridges the gap between traditional botanical extracts and modern precision medicine by enhancing the skin's endogenous defenses.
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