Science
Mechanism of Action
This extract operates through 'mitophagy'—a cellular quality control process mediated by the FUNDC1 pathway that clears out damaged mitochondria to restore optimal energy metabolism. Simultaneously, it strengthens the skin's physical barrier by upregulating structural proteins like Claudin-1 and Loricrin while inhibiting MMP-1 enzymes to preserve the existing collagen matrix.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Demonstrated over 120% increase in cell viability and significant promotion of Type III collagen and elastin synthesis.
- 02 In-vitro activation of mitochondrial autophagy leading to a marked reduction in reactive oxygen species (ROS) within senescent fibroblasts.
Transparency
Dusting Analysis
Due to its high cost and 'prestige' botanical status, it is frequently included at 'label-claim' levels (below 0.5%). For meaningful mitochondrial repair and barrier protein induction, concentrations of 1% to 5% are required.
The Formula
Formulation
Stability
Highly thermolabile bioactive; must be processed under cold-process conditions (below 40°C) to maintain the integrity of the meristem cell metabolites.
Synergies
- Niacinamide
- Glycerin
- Hyaluronic Acid
- Peptides
Conflicts
- High heat (>50°C)
- Strong oxidizers
- Extreme alkaline conditions (>pH 8.0)
Safety
Safety Profile
Extensive HRIPT testing confirms the extract is non-sensitizing and non-irritating even at high concentrations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An elite regenerative active that excels in mitochondrial detoxification and barrier protein synthesis when formulated at concentrations above 1%.
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References
Sources