Science
Mechanism of Action
It operates through a four-pronged approach: activating the FUNDC1-mediated mitophagy pathway to clear damaged mitochondria and reverse senescence; inhibiting MMP-2 and elastase enzymes to protect the structural matrix; upregulating Claudin-1 to seal the epidermal barrier; and neutralising oxidative stress via a rich profile of polyphenols and flavonoids.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Demonstrated significant SOD-like radical scavenging and promotion of Type I collagen synthesis in human skin cells at 1.0% concentration.
- 02 Shown to protect the stratum corneum from UVB-induced carbonylation, with green leaf extracts outperforming mature leaf variants in antioxidant capacity.
- 03 In vitro fibroblast testing (15-60 μg/L) confirmed enhanced DNA repair and anti-aging effects through mitochondrial rejuvenation.
Transparency
Dusting Analysis
Due to its premium positioning, it is frequently included at 'claim' levels below 0.1%. For meaningful biological impact on collagen synthesis and DNA repair, concentrations between 0.5% and 1.0% are clinically required.
The Formula
Formulation
Stability
The bioactive polyphenols are thermo-labile; the extract should be incorporated during the cooling phase at temperatures below 40°C to maintain potency.
Synergies
- Vitamin C
- Hyaluronic Acid
- Niacinamide
Conflicts
- Strong oxidizing agents
- High alkaline conditions (pH > 8.0)
Safety
Safety Profile
Extensive testing including HRIPT and primary irritation trials at 1.0% confirm an excellent safety profile for topical use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional precision botanical for anti-aging and barrier defense, provided it is formulated at active concentrations rather than marketing levels.
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References
Sources