Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle

CALYSTEGIA SEPIUM EXTRACT.

Valuable / ANTIOXIDANT

A sophisticated botanical derivative from Hedge Bindweed that provides robust antioxidant protection through its unique concentration of δ-tocopherol. This extract is engineered to support cellular health by stabilizing damaged keratinocytes and maintaining skin barrier integrity.

Antioxidant Skin Conditioning Cellular Regulation

Science

The extract functions as a bio-active shield, utilizing high-purity tocopherols to neutralize free radical cascades. At the cellular level, it modulates the G0/G1 cell cycle phase and influences NF-κB1 and APAF1 expression, which facilitates the orderly transition and turnover of damaged epidermal cells.


Research

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated significant antiproliferative activity and cellular regulation in keratinocyte models, inducing targeted cell cycle arrest to prevent the propagation of damaged cells.

Transparency

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

Because it is a botanical extract with specific cellular modulation properties at micro-concentrations, it is frequently used at trace levels (below 0.1%) for marketing claims rather than functional antioxidant protection.


The Formula

Solubility
Both
Optimal pH 4.5 – 6.5
0 7 14

Stability

The extract contains both hydrophilic calystegines and lipophilic tocopherols; stability is maximized when housed in a glycerin or water-butylene glycol delivery system.

Synergies

  • Vitamin E
  • Glycerin
  • Hyaluronic Acid

Conflicts

  • Strong oxidizing agents
  • High-alkaline formulations (pH > 7.0)

Safety

CIR Status
Not reviewed
Pregnancy
Safe
Sensitization risk Low

While the raw plant sap can be an agricultural irritant, the refined cosmetic extract is well-tolerated and listed in the EU Glossary of Cosmetic Ingredients.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A high-performance botanical extract that offers more than basic hydration by actively participating in cellular damage control and oxidative defense.


Related

Finding similar ingredients…