Science
Mechanism of Action
The extract operates by stimulating fibroblast proliferation, which is essential for collagen synthesis and rapid wound healing. It utilizes a unique trio of bioactive compounds: calophyllolide for its antimicrobial action, calophyllic acid to suppress pro-inflammatory cytokines like IL-1β and TNF-α, and a high concentration of delta-tocotrienols (Vitamin E) to provide robust antioxidant protection against oxidative stress.
Research
Clinical Evidence
High confidence20%
Key findings
- 01 Twice-daily application over a 6–9 week period resulted in a significant reduction in the size and visibility of scars older than 12 months.
- 02 Bigel formulations outperformed standard commercial oils in accelerating tissue repair and improving anti-scarring outcomes in excision models.
Transparency
Dusting Analysis
While many botanical extracts are added at negligible levels for marketing, Tamanu's reparative benefits for scars and inflammation typically require concentrations of 5% or higher to match clinical results.
The Formula
Formulation
Stability
Highly stable in standard emulsion systems; however, the lipid components within the extract are sensitive to photo-oxidation and air exposure, requiring airtight or opaque packaging.
Synergies
- Vitamin E
- Glycerin
- Hyaluronic Acid
Conflicts
- Strong oxidizing agents
Safety
Safety Profile
Reviewed by the CIR in 2018; determined to be safe and non-irritating when formulated correctly.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional restorative agent that bridges the gap between traditional botanical medicine and precision clinical repair for scarred or compromised skin.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources