Science
Mechanism of Action
The extract utilizes a synergistic complex of jacareubin (a xanthone), inophyllums (coumarins), and quercetin (a flavonoid). These compounds work in tandem to disrupt bacterial cell membranes and modulate reactive oxygen species (ROS) levels, effectively inhibiting lipid peroxidation and neutralizing free radicals while suppressing inflammatory triggers like EGFR proteins.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 Demonstrated significant antimicrobial efficacy against S. aureus and P. aeruginosa at concentrations ≤50 µg/ml via Inophyllum E isolation.
- 02 Achieved peak antioxidant scavenging capacity (IC50) at a precise concentration of 0.054 µg/ml using methanolic extraction.
- 03 Exhibited concentration-dependent cytoprotective and apoptotic modulation in human cell line models at 120 µg/ml.
Transparency
Dusting Analysis
Botanical extracts like Tamanu leaf are frequently used at trace levels (<0.01%) for marketing purposes. However, research indicates that antimicrobial and antioxidant activity is biologically relevant even at low parts-per-million (ppm) concentrations.
The Formula
Formulation
Stability
Bioactive phenols are water-soluble, while xanthones require non-polar phases. It is most stable when integrated into microemulsions or emulgels to maintain the integrity of sensitive phenolic compounds.
Synergies
- Vitamin E
- UV Filters (SPF boosting)
- Hyaluronic Acid
Conflicts
- Strong oxidizing agents
- Highly alkaline environments (pH > 7.0)
Safety
Safety Profile
While the seed oil is widely recognized, the leaf extract specifically lacks a full CIR safety profile. Acute dermal tests suggest it is non-irritating at standard cosmetic dosages.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance botanical that provides essential antioxidant defense and microbial balance, particularly effective in precision formulations for inflammatory skin conditions.
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References
Sources
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