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CALENDULA OFFICINALIS MERISTEM CELL EXTRACT.

Valuable / ANTIOXIDANT

A high-performance plant stem cell derivative engineered to accelerate dermal repair and structural fortification. Unlike traditional botanical extracts, this meristematic cell culture delivers a concentrated payload of exosomes and growth factors to stimulate biological skin renewal.

antioxidant soothing skin conditioning regenerative anti-aging

Science

This extract functions as a bio-stimulatory signaling agent, promoting the expression of TGFβ1 and bFGF growth factors to catalyze fibroblast proliferation. It leverages a rich composition of plant-derived exosomes, peptides, and polysaccharides to inhibit nitric oxide production for anti-inflammatory effects while neutralizing oxidative stress through cellular protection.


Research

High confidence
Effective range 1–5%
Optimal

4%

Key findings

  1. 01 A 28-day clinical evaluation of a 4% concentration demonstrated a 38.3% reduction in wrinkle depth and a 58.3% increase in skin thickness.
  2. 02 In vitro testing at 1.0% showed a 40% increase in cell survival against oxidative-induced stress in human keratinocytes.

Transparency

Commonly dusted
Min. effective
1%
Red flag below
0.5%

Due to its high cost and 'stem cell' marketing appeal, it is frequently included at negligible levels (under 0.1%). For measurable improvements in skin density and moisture (74% increase), a concentration of at least 1-4% is required.


The Formula

Solubility
Water
Optimal pH 4 – 6.5
0 7 14

Stability

Highly thermolabile; exposure to high temperatures degrades its antioxidant profile. Requires storage between 4-22°C and should be added during the cool-down phase of formulation.

Synergies

  • Glycerin
  • Propanediol
  • Hyaluronic Acid

Conflicts

  • Strong oxidizing agents
  • High ethanol concentrations
  • pH levels exceeding 7.5

Safety

CIR Status
Safe as used
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

Recognized for exceptional tolerance, making it a gold-standard choice for sensitive skin and pediatric care.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A potent biotechnological active that offers significant measurable improvements in skin thickness and wrinkle depth when formulated at efficacious percentages.


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References