Science
Mechanism of Action
By acting as a high-solubility vehicle, it delivers calcium ions directly to the epidermis to regulate the calcium gradient necessary for proper keratinocyte differentiation. It triggers the synthesis of essential intercellular lipids—specifically ceramides and cholesterol—while upregulating tight junction proteins like occludin to seal the skin barrier and prevent transepidermal water loss.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 In vivo testing at a 2% concentration demonstrated significant improvements in skin smoothness, moisture retention, and barrier recovery over an 8-week period.
- 02 In vitro analysis at 0.1% confirmed enhanced expression of involucrin and claudin-4, markers essential for cellular maturation and tight junction formation.
Transparency
Dusting Analysis
While physiological benefits are observed at concentrations as low as 0.1% in cellular models, formulated products claiming significant barrier repair should ideally utilize levels closer to 2% to mirror clinical results. Inclusion below 0.1% is likely for marketing purposes.
The Formula
Formulation
Stability
Exhibits exceptional thermal stability up to 90°C and maintains structural integrity across a broad pH spectrum, making it more versatile than standard calcium lactate.
Synergies
- Ceramides
- Glycerin
- Phospholipids
Conflicts
- Carbomers (calcium ions can trigger polymer collapse)
- Anionic surfactants
- High-concentration phosphate solutions
Safety
Safety Profile
Recognized as safe for both topical and oral applications; categorized under phosphoric acid salts by the CIR and approved by EFSA.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An expertly engineered mineral delivery system that is essential for restoring a compromised skin barrier and optimizing cellular maturation.
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